9/20/2023 0 Comments 3 major body fluid compartments![]() ![]() Overviewįluid compartments in the mammalian body broadly comprise two compartments, each with several subdivisions: List of terms related to Fluid compartmentsĮditor-In-Chief: C. Risk calculators and risk factors for Fluid compartmentsĬauses & Risk Factors for Fluid compartmentsĭiagnostic studies for Fluid compartments US National Guidelines Clearinghouse on Fluid compartmentsĭirections to Hospitals Treating Fluid compartments Ongoing Trials on Fluid compartments at Clinical Ĭlinical Trials on Fluid compartments at Google Most cited articles on Fluid compartmentsĪrticles on Fluid compartments in N Eng J Med, Lancet, BMJĬochrane Collaboration on Fluid compartments The total body water is divided into compartments and useful physiological insight and some measure of clinical predictability can be gained from this approach even though most of these fluid compartments do not exist as discrete real fluid collections.Most recent articles on Fluid compartments The electrolyte composition of the various transcellular fluids are quite dissimilar and typical values or ranges for some of these fluids are listed in the Table. The fluid fluxes involved with GIT fluids can be quite significant. It is important because of the specialised functions involved. It includes CSF, GIT fluids, bladder urine, aqueous humour and joint fluid. It is contained within epithelial lined spaces. Transcellular fluid is a small compartment that represents all those body fluids which are formed from the transport activities of cells. ![]() ![]() This fluid is mobilised only very slowly and this lessens its importance when considering the effects of acute fluid interventions. The fluid of bone & dense connective tissue is significant because it contains about 15% of the total body water. The fluid compartment called the blood volume is interesting in that it is a composite compartment containing ECF (plasma) and ICF (red cell water). Blood contains suspended red and white cells so plasma has been called the interstitial fluid of the blood. It differs from ISF in its much higher protein content and its high bulk flow (transport function). Plasma is the only major fluid compartment that exists as a real fluid collection all in one location. Lymph is more easily obtained for analysis than other parts of the ISF. The lymphatic system returns protein and excess ISF to the circulation. Lymph is considered as a part of the ISF. ISF has the compositional characteristics of ECF (as mentioned above) but in addition it is distinguished by its usually low protein concentration (in comparison to plasma). Oxygen, nutrients, wastes and chemical messengers all pass through the ISF. The ISF bathes all the cells in the body and is the link between the ICF and the intravascular compartment. This is also a virtual fluid (ie it exists in many separate small bits but is spoken about as though it was a pool of fluid of uniform composition in the one location). Interstitial fluid (ISF) consists of all the bits of fluid which lie in the interstices of all body tissues. The ECF compositional similarity is in some ways, the opposite of that for the ICF (ie low in potassium & magnesium and high in sodium and chloride). These compartments are distinguished by different locations and different kinetic characteristics. The ECF is divided into several smaller compartments (eg plasma, Interstitial fluid, fluid of bone and dense connective tissue and transcellular fluid). The use of this convention allows predictions to be made about what will happen with various interventions and within limits these are physiologically meaningful.Ī similar argument applies to the Extracellular Fluid. Behaviour: Intracellular fluids behave similarly to tonicity changes in the ECFīecause of this physiological usefulness, it is convenient to talk of an idealised ICF as though it were a single real entity.Composition: Intracellular fluids are high in potassium and magnesium and low in sodium and chloride ions.Location: The distinction between ICF and ECF is clear and is easy to understand: they are separated by the cell membranes.In particular, similarities of location, composition and behaviour: How can the term intracellular fluid be used as though it was a single body of fluid? The reason is that though not united physically, the collections have extremely important unifying similarities which make the ICF concept of practical usefulness in physiology. The ICF compartment is really a "virtual compartment" considered as the sum of this huge number of discontinuous small collections. The concept of a single united "compartment" called intracellular fluid is clearly artificial. The Intracellular Fluid is composed of at least 10 14 separate tiny cellular packages. ![]()
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